(R)-4-oxo-5-phosphononorvaline: a new competitive glutamate antagonist at the NMDA receptor complex

J Med Chem. 1990 Nov;33(11):2961-3. doi: 10.1021/jm00173a009.

Authors

J P Whitten¹, B M Baron, D Muench, F Miller, H S White, I A McDonald

Affiliation

¹ Merrell Dow Research Institute, Cincinnati Center, Ohio 45215.

PMID: 1977908
DOI: 10.1021/jm00173a009

No abstract available

MeSH terms

Animals
Binding, Competitive
Cerebellum / drug effects
Cerebellum / metabolism
Cyclic GMP / metabolism
Excitatory Amino Acid Antagonists*
Glutamates / metabolism
Glutamic Acid
Kindling, Neurologic / drug effects
Mice
Mice, Inbred DBA
N-Methylaspartate / antagonists & inhibitors
N-Methylaspartate / metabolism*
N-Methylaspartate / pharmacology
Rats
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
Receptors, N-Methyl-D-Aspartate / metabolism
Valine / analogs & derivatives*
Valine / chemical synthesis
Valine / chemistry
Valine / metabolism

Substances

Excitatory Amino Acid Antagonists
Glutamates
Receptors, N-Methyl-D-Aspartate
4-oxo-5-phosphononorvaline
Glutamic Acid
N-Methylaspartate
Cyclic GMP
Valine